The destruction of isonicotinic acid hydrazide in the presence of haemin.

Metal-catalysed auto-oxidation of isoniazid.

Isoniazid (isonicotinic acid hydrazide) is stable in the solid state and in concentrated aqueous solutions. In dilute aqueous solutions, however, it breaks down under certain conditions. This breakdown has been shown to require oxygen (and hence may be described as an auto-oxidation) and certain metal ions, either free, such as Mn2+, Cu2+, Fe"+, or combined as haemin; and to be accelerated by i...

Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene)hydrazide

Eight new complexes of Cu(II), Co(II), Ni(II) and Zn(II) with isonicotinic acid hydrazide (isoniazid, (INH)) and isonicotinic acid (1-naphthylmethylene)hydrazide (INNMH), having the formula of the type [M(INH)(ac)2] or [M(INNMH)(ac)2] (M = Co(II), Ni(II) and Zn(II)) and [Cu(INH)(ac)2]2, [Cu(INNMH)(ac)2]2, were synthesized and characterized. All complexes were characterized based on elemental an...

Charge Transfer Interactions between Isonicotinic Acid Hydrazide and Cupric Ions

The interaction of Cu2+ with isonicotinic acid hydrazide (INH) and some of its derivatives has been investigated by means of electron spin resonance, nuclear magnetic resonance, and optical absorption studies. It could be shown that an interaction exists between the metal ions and the hydrazine side chain in addition to the very weak interaction with the ring nitrogen. The results obtained indi...

Isonicotinic Acid Hydrazide

Radical scavenging activities of niacin-related compounds.

We investigated whether niacin-related compounds had radical-scavenging activity by electron spin resonance methods. Many compounds, but not trigonelline, had radical-scavenging activity against hydroxyl radicals. However, for the nitric oxide radical and 1,1-diphenyl-2-picrylhydrazyl radical, only nicotinic acid hydrazide and isonicotinic acid hydrazide had scavenging activities. These results...